Delayed sensitivities to peptides in dairy can present up to 72 hours after consuming dairy foods. These sensitivities are based on IgG or IgA antibody-driven reactions and can affect both the local intestinal environment with acute symptoms, as well as the extra-intestinal systems from the skin, to the joints, brain, and other internal organs and tissue systems.

Detecting sensitivity to cow’s milk can be difficult due to its ubiquitous presence in the Western diet, symptom overlap with other common conditions, and the often-delayed nature of sensitivity symptoms.